Friday, January 3, 2020
Lung Cancer A Malignant Transformation And Growth
Lung Cancer Screening Lung cancer is a malignant transformation and growth of the cells of the lung and the airway tissues. It is usually divided into two main types: Small Cell Lung Cancer (SCLC, 15%) and Non-Small Cell Lung Cancer (NSCLC, 85%) with the latter further subdivided into several subtypes such as Squamous, Large Cell, and Adenocarcinoma among other rare subtypes. Each subtype has its own unique growth and spread pattern with some being more aggressive than others. Lung cancer is staged according to the American Joint Committee by the TNM system, where T stands for the size, N for nodal involvement and M for the presence of distant metastases. The knowledge of the lung cancer main types, subtypes and stage, and the presence of specific molecular and genetic signatures, help the clinician determine the treatment approaches be it surgical, radiation, chemotherapy and the combination of, in addition to the appropriate type of chemotherapy. Lung cancer has been the most common cancer in the world for several decades. The International Agency for Research on Cancer (IARC) estimates for 2012 was 1.8 million new cases which constituted 12.9% of the total number of new cancers diagnosed worldwide. Fifty eight percent of which occurred in the less developed regions. Lung cancer remains the most common cancer in men worldwide (1.2 million, 16.7% of the total) with the highest estimated age-adjusted incidence rates in Central and Eastern Europe (53.5 per 100,000) andShow MoreRelatedLung Cancer : A Malignant Cellular Transformation And Growth Of The Lung And The Airway Tissues3080 Words à |à 13 Pages Lung cancer is a malignant cellular transformation and growth of the lung and the airway tissues. It is usually divided into two main types: Small Cell Lung Cancer (SCLC, 15%) and Non-Small Cell Lung Cancer (NSCLC, 85%) with the latter further subdivided into several subtypes such as Squamous carcinoma, Large Cell carcinoma, and Adenocarcinoma among other rare subtypes. Each subtype has its own unique growth and spread pattern with some being more aggressive than others. Lung cancer is staged accordingRead MoreEssay about Cancer1518 Words à |à 7 PagesCancer à à à à à Right now, cancer is one of the most feared diseases in the world. In the early 1990s almost 6 million new cancer cases developed and more than 4 million deaths from cancers occurred. Also more than one-fifth of all deaths were caused by cancer and it has been predicted, by the American Cancer Society, that about 33% of Americans will eventually develop this disease. This is a huge disease that is killing people all over the world. à à à à à The field of cancer study is called OncologyRead MoreThe Four Main Types Of Blood Cancers814 Words à |à 4 PagesThere are four main types of blood cancers: acute myeloid leukemia (AML), chronic myeloid leukemia (CML), acute lymphocytic leukemia (ALL), and chronic lymphocytic leukemia (CLL). AML and ALL can become fatal within in a few weeks or month if not properly treated. CML and CLL has a slower progression rate than there chronic counterparts. Patients with AML or ALL tend to have noticeable symptoms whereas patients with CML or CLL tend to be asymptomatic (Hallek, 2015). Even though chronic leukemia progressesRead MoreNeoplasia10526 Words à |à 43 PagesFMCPath) Senior Lecturer and Consultant Histopathologist University of Uyo Teaching Hospital,Uyo, Akwa- Ibom State, Nigeria. Neoplasia means the process of new growth whilst Neoplasm means a new growth. 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Chemoresistance is simply when rapidly growing cancer cells that used to be affected and destroyed by antineoplastic drugs stop responding and start to grow again. When cancer cells are tolerated to some anticancerRead MoreMatrix Mettaloproteinase 3 : A Potential Biomarker For Human Metastatic Osteosarcoma1711 Words à |à 7 Pagesexpression of MMP-3 in human osteosarcoma and associated with tumor metastasis Abstract: Matrix metalloproteinase-3 (MMP-3, is one of several matrix metalloproteinases (MMPs) family that has been observed in several malignant tumors, including breast, colon, cervical and lung cancers, where its expression correlates with the invasion and metastasis of these tumors. However, the roles of MMP-3 in osteosarcoma are totally unknown. In this study, we examined the expression of MMP-3 in 15 primary andRead MoreAdjuvants In Vaccines1587 Words à |à 7 PagesThe viruses that cause tumorigenic transformation produce oncoviral antigens. These antigens are recognized by the immune system as ââ¬Å"non-selfâ⬠because they are present on infected cells (Saxena and Bhardwaj 2017). Neoantigens, which are MHC restricted antigens, are produced by mutations in tumor cells so they are not found on all tumors. Because neoantigens are unique to the individual, vaccines that target these antigens need to be personalized (Saxena and Bhardwaj 2017). Finally, antigens thatRead MoreCancer Immunology2728 Words à |à 11 PagesCancer: Cancer can be defining as disease condition in which cell divide and proliferate uncontrollably bypassing the normal rules of cell division. It is characterized by a progression of changes on cellular and genetic level that ultimately reprogram a cell to undergo uncontrolledà cell division, thus forming a malignant mass. Carcinogenesis: Cancers consist of single clones or several clones of cells that are capable of partially (benign tumor) or fully (malignant cancer) independent
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